Study on Rapid Optimizing Cell Inductive Differentiation Routes

点击翻译按钮获取中文摘要

Using a gene expression database of mesenchymal stem cells and various cells differentiated from them, we have invented two informatics methods to select candidates of cell differentiation induction factors. In one method we have shown that there are two out of top five candidates actually promote the adipocyte differentiation. In another method we have shown that we use only a few hundreds known data out of about 20, 000 human genes and predict cell differentiation factors with high accuracy. Furthermore, we have established an experimental method to use proteins as combinatorial induction system of multiple factors.