Change of oligosaccharides in cell adhesion, and its roles

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The functional units of cell adhesion are typically multiprotein complexes made up of three general classes of proteins; the adhesion receptors, the cell-extracellular matrix (ECM) proteins, and the cytoplasmic proteins. The cell adhesion receptors are usually transmembrane glycoproteins (for example E-cadherin and integrin) that mediate binding at the extracellular surface and determine the specificity of cell-cell and cell-ECM recognition. The most of these adhesive proteins are glycosylated. In the present study, we clearly demonstrated that N-glycosylation is important for integrin-mediated cell migration and intracellular signaling, a mutual regulation between the N-glycan expression and E-cadherin-mediated cell adhesion, and the underlying molecular mechanisms.