Mechanism of DNA methylation inheritance by Dnmt1

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DNA methyltransferase 1(Dnmt1) plays an important role in the inheritance of genomic DNA methylation in mammals. Dnmt1 localizes to DNA replication foci in a cell-cycle-dependent manner. However, it remains elusive which domains of Dnmt1 are required for this process and how this process is regulated. By scanning mutagenesis, we identified several domains required for the regulation of Dnmt1 localization. Our results suggest that the intra-molecular interaction is important for Dnmt1 localization.