Research on a disturbance mechanism of endocrine system of host by an insect virus.

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Whole genome sequences of entomopoxviruses revealed the viruses had an important gene for manipulation of the host endocrine. Using cultured cell that was found to support an entomopoxvirus replication in present research, knock-out mutant lacking this gene function was constructed. Juvenile hormone(JH) titer of the hosts infected with wild type virus was maintained to be high, resulting in host's death in larval stage. On the other hand, JH titer of the hosts infected with the gene function-defective virus was similar to that of healthy hosts, which allowed infected hosts to develop toward pupation. These findings indicate that entomopoxviruses have a gene that disturbs JH titer to manipulate hosts development.