Study on the molecular mechanisms of the fungal cell-wallβ-1, 6-glucan biosynthesis

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The molecular mechanism of biosynthesis ofβ-1, 6-glucan, an essential component of the yeast cell wall, is still unclear. Kre6 and its homologue Skn1, which have sequence homology with glycoside hydrolases, are required for this process. In this study, we discovered that Kre6 and Skn1 interact with the ER-resident proteins Keg1, a part of Kre6/Skn1 must localize to the plasma membrane of growing buds forβ-1, 6-glucan synthesis, and their proper folding and localization to the growing buds require support of Keg1 and Cne1 in the ER.