Novel Dosage form design for ocular and pulmonary drug delivery based on analysis of behavior of nano-particle as drug carrier

本研究项目的目的是开发无创给药系统，以促进几种给药途径的给药。本研究针对两种给药途径；一种是治疗眼后部疾病的眼部给药系统，另一种是用于局部和全身给药的肺系统，用于吸收性差的药物，如肽药物。我们成功地设计了眼给药脂质体系统的最佳颗粒设计，并通过脂质体滴眼液证明了其对视网膜损伤的积极药理作用。用合适的聚合物对脂质体颗粒进行表面修饰，可大大改善其效果。在肺部给药中，聚合物表面修饰可以控制给药后载体颗粒的滞留。利用该脂质体系统，在动物实验中观察到多肽药物的长效药理作用。这些结果可以强有力地支持开发非侵入性给药系统，以替代以前的侵入性给药，如注射。

The purpose of this research project is development of noninvasive drug delivery systems to promote drug delivery in several administration routes. Two administration routes are targeted in this study ; One is ophthalmic delivery system to treat the diseases in posterior part of the eye and another is pulmonary system for both topical and systemic drug delivery for poorly absorbable drug such as a peptide drug. We succeeded in design of optimum particulate design of ocular delivery liposomal system and demonstrated its positive pharmacological effects on damage in retina with the liposomal eye drops. The effects are much improved by surface modification of the liposomal particles with suitable polymers. In pulmonary drug delivery, surface modification with polymers could control the retention of the carrier particles after administration. By using this liposomal system, a prolonged pharmacological effect of the peptide drug was observed in animal experiments. These results can strongly support to develop non-invasive drug delivery systems as an alternative to the former invasive drug administration such as an injection.