Novel Dosage form design for ocular and pulmonary drug delivery based on analysis of behavior of nano-particle as drug carrier

基于纳米粒子作为药物载体行为分析的眼部和肺部药物递送新剂型设计

• 批准号: 21390011
• 负责人: TAKEUCHI Hirofumi
• 金额: $ 11.81万
• 依托单位: Gifu Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390011/
• 关键词: 製剤学; リポソーム; 局所体内挙動; 網膜; 点眼剤; 微粒子; リモートローディング; 経肺投与; 抗炎症薬; ステロイド; ペプチド

The purpose of this research project is development of noninvasive drug delivery systems to promote drug delivery in several administration routes. Two administration routes are targeted in this study ; One is ophthalmic delivery system to treat the diseases in posterior part of the eye and another is pulmonary system for both topical and systemic drug delivery for poorly absorbable drug such as a peptide drug. We succeeded in design of optimum particulate design of ocular delivery liposomal system and demonstrated its positive pharmacological effects on damage in retina with the liposomal eye drops. The effects are much improved by surface modification of the liposomal particles with suitable polymers. In pulmonary drug delivery, surface modification with polymers could control the retention of the carrier particles after administration. By using this liposomal system, a prolonged pharmacological effect of the peptide drug was observed in animal experiments. These results can strongly support to develop non-invasive drug delivery systems as an alternative to the former invasive drug administration such as an injection.

本研究的目的是开发非侵入性药物输送系统，以促进药物在几种给药途径中的输送。本研究针对两种给药途径;一种是用于治疗眼后部疾病的眼部给药系统，另一种是用于吸收不良药物（如肽类药物）的局部和全身给药的肺部系统。我们成功地设计了脂质体眼内给药系统的最佳微粒设计，并证明了脂质体滴眼液对视网膜损伤的积极药理作用。通过用合适的聚合物对脂质体颗粒进行表面改性，效果大大改善。在肺部给药中，用聚合物进行表面修饰可以控制给药后载体颗粒的滞留。通过使用该脂质体系统，在动物实验中观察到肽药物的长期药理作用。这些结果可以有力地支持开发非侵入性给药系统作为替代以前的侵入性给药，如注射。

项目成果

ナノ材料の医療応用

纳米材料的医学应用

• 发表时间: 2012
• 作者: A. Mizutani;K. Nagase;A. Kikuchi;H. Kanazawa;Y. Akiyama;J. Kobayashi;M. Annaka;T. Okano;中原靖人;竹内洋文
• 通讯作者: 竹内洋文

最近の製剤設計と製剤プロセス化学工学会

最新配方设计和配方工艺化学工程学会

• 发表时间: 2011
• 作者: Ishikawa;S.;Tanaka;Y.;Takahashi-Niki;K.;Niki;T.;Ariga;H.;Iguchi-Ariga;S. M. M.;Takashi Ohshima;竹内洋文
• 通讯作者: 竹内洋文

リポソームによる眼科DDS

脂质体眼科 DDS

• 发表时间: 2011
• 作者: Hiroki Kobayashi;Mayumi Nishikawa;Chikako Sakamoto;Tadashi Nishio;Hideko Kanazawa;Teruo Okano;竹内洋文
• 通讯作者: 竹内洋文

Design of a liposomal ocular delivery system targeting the posterior segments of the eye

针对眼后段的脂质体眼部递送系统的设计

• 发表时间: 2011
• 作者: K.Hironaka;Y.Tozuka;K.Tahara;H.K.Tsuruma;M.Shimazawa;Hara. H.;Takeuchi. H.
• 通讯作者: Takeuchi. H.

Eyedrop administration of edaravone-loaded liposomes protected against light-induces retinal damage

负载依达拉奉的脂质体的滴眼剂可防止光诱导的视网膜损伤

• 发表时间: 2011
• 作者: K.Hironaka;H.Shimazaki;T.Fujisawa;Y.Tozuka;K.Tsuruma;M.Shimazawa;H.Hara;H.Takeuchi
• 通讯作者: H.Takeuchi