Studies on novel mechanisms of environmental chemicals-induced toxicity using arachidonate-metabolizing enzyme genetically modified mice

为了阐明环境化学物质诱导毒性的新机制，我们重点研究了花生四烯酸代谢作为有毒化学物质的靶点，并研究了花生四烯酸代谢酶转基因小鼠的表型。结果表明，几种花生四烯酸代谢酶参与了化学物质诱导的男性生殖毒性、神经毒性、肾积水和癌变的发生，并表明其他酶可能是化学物质诱导毒性的靶点。

In order to clarify novel mechanisms of environmental chemicals-induced toxicity, we focused on arachidonate metabolism as a target of toxic chemicals and investigated phenotypes of arachidonate-metabolizing enzyme genetically modified mice. As the results, we demonstrated that several arachidonate-metabolizing enzymes are involved in chemicals-induced male reproductive toxicity, neurotoxicity, onset of hydronephrosis and carcinogenesis, and indicated that other enzymes could be targets of chemicals-induced toxicity.