Crosstalk between nuclear receptor and transcription cofactor on brain development and its modulation by environmental chemicals.

使用甲状腺激素（TH）分析了重复引用的主题。TH受体（TR）系统作为模型系统。先天性甲状腺功能低下大鼠在新环境下表现出多动性。我们发现，这种效果是由多巴胺转运中断，由于减少微管蛋白的表达，这是由TH。在原代小脑培养，TH诱导树突和神经突伸长，这是抑制环境化学品，如多溴二苯醚（PBDE）的增加。多溴二苯醚没有改变TR-辅因子结合。相反，它将TR与DNA分离。

Above-referenced theme was analyzed using thyroid hormone (TH) . TH receptor (TR) system as a model system. Congenital hypothyroid rat showedhyperactivity under novel environment. We found that the effect is induced by disruption of dopamine transport due to a decreased tubulin expression, which is regulated by TH.In primary cerebellar culture, TH induced an increase in dendrite and neurite elongation,which was inhibited by environmental chemicals such as polybrominated diphenylether(PBDE). PBDE did not alter TR-cofactor binding. Instead, it dissociated TR from DNA.