New drug development for hyperuricemia targeting novel urate efflux transporter URATv1

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The purpose of this study was to clarify the mechanism for the onset of hyperuricemia and to develop a novel uricosuric drug targeting renal urate transporters by analyzing transgenic mice of urate efflux transporter URATv1 that expresses at the basolateral side of renal proximal tubules and the selection of candidate compounds that inhibit urate transport using URATv1 expression system. As a consequence, I could demonstrate experimentally that URATv1, functions as a basolateral urate exit, contributes to the reduced urinary urate excretion and found the important structure for raising novel uricosuric drug targeting URAT1.