MAINTENANCE OF PROTEIN HOMEOSTASIS REGULATED BY HEAT SHOCK FACTOR

细胞蛋白质稳态（proteostasis）能力或蛋白质错误折叠的缓冲能力与衰老和衰老相关的蛋白质错误折叠疾病有关。热休克反应是维持蛋白质平衡能力的重要机制之一，主要在转录水平上由热休克因子（heat shock factor， HSF）调控。在本研究项目中，我们首次证明了HSF1不仅通过调节促进蛋白质折叠的热休克蛋白（HSPs），还通过调节具有多种功能的非hsp蛋白（包括蛋白质降解）来控制蛋白质静止能力。

Cellular protein homeostasis(proteostasis) capacity, or buffering capacity of protein misfolding, is related with aging and aging-associated protein misfolding diseases. One of prominent mechanisms of the maintenance of proteostasis capacity is the heat shock response, which is regulated mainly at the level of transcription by heat shock factor(HSF). In this research project, we first demonstrate that HSF1 controls proteostasis capacity by regulating not only heat shock proteins(HSPs), which facilitate protein folding, but also non-HSP proteins with diverse function including protein degradation.