MAINTENANCE OF PROTEIN HOMEOSTASIS REGULATED BY HEAT SHOCK FACTOR

点击翻译按钮获取中文摘要

Cellular protein homeostasis(proteostasis) capacity, or buffering capacity of protein misfolding, is related with aging and aging-associated protein misfolding diseases. One of prominent mechanisms of the maintenance of proteostasis capacity is the heat shock response, which is regulated mainly at the level of transcription by heat shock factor(HSF). In this research project, we first demonstrate that HSF1 controls proteostasis capacity by regulating not only heat shock proteins(HSPs), which facilitate protein folding, but also non-HSP proteins with diverse function including protein degradation.