Controlling of chronic inflammatory diseases via regulation of inflammation stroma cells

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We defined the inflammation stroma cells as cells having excessive chenokine production after NFkB and STAT3 stimulation. The inflammation stroma cells have type 1 collagen molecules and include endothelial cells, fibroblasts, astrocytes, and epithelial cells. The main founding in this project is that excessive activation of the he inflammation stroma cells by an excessive neural activation particularly via sympathetic neuron' s creates a gateway for immune cells in blood vessels including autoreactive CD4+ T cells followed by the development of an autoimmune disease.