Elucidation of neuroprotective mechanisms of low molecular weight compounds
Elucidation of neuroprotective mechanisms of low molecular weight compounds
批准号:
21390175
负责人:
AKAIKE Akinori
金额:
$12.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
We examined the pharmacological effects of serofendic acid, a low molecular weight substances isolated from fetal bovine serum. We revealed that serofendic acid had a protective effect against toxicity induced by amyloidβprotein and serofendic acid significantly reduced infarct volume in rat myocardial infarction model. In addition, we examined the neuroprotective mechanism of nicotinic acetylcholine. We showed that donepezil, an inhibitor of acetylcholinestrase, reduced the increase in the intracellular concentration of calcium induced by glutamate.
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DOI:
--
发表时间:
2010
期刊:
影响因子:
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作者:
[大西正俊, 香月博志, 井上敦子, 泉安彦, 久米利明, 赤池昭紀]
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赤池昭紀
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DOI:
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发表时间:
2009
期刊:
影响因子:
--
作者:
[Feiye Guo, 馬寧, 川西正祐, 村田真理子, 平工雄介, 赤池昭紀]
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发表时间:
2010
期刊:
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他10名
医薬品開発論
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发表时间:
2010
期刊:
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作者:
[柴崎正勝、赤池昭紀、橋田充, 他14名]
通讯作者:
他14名
実務実習事前学習のための調剤学
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DOI:
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发表时间:
2009
期刊:
影响因子:
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作者:
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通讯作者:
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