Role of intracellular degradation systems in genesis of heart failure
Role of intracellular degradation systems in genesis of heart failure
批准号:
21390240
负责人:
OTSU Kinya
金额:
$11.4万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
In this study, we examined the role of degradation systems in the genesis of heart failure. Our results indicate that calpain plays a cardioprotective role and autophagy is important to maintain cardiac function during aging. Furthermore, DNase II regulates inflammatory responses in the heart by degrading mitochondrial DNA.
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DOI:
10.1074/jbc.m111.248088
发表时间:
2011-09-16
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Taneike, Manabu, Mizote, Isamu, Otsu, Kinya]
通讯作者:
Otsu, Kinya
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Yamamizu K, Furuta S, Katayama S, Narita M, Kuzumaki N, Imai S, Nagase H, Suzuki T, Narita M, Yamashita JK, 大津欣也]
通讯作者:
大津欣也
The in vivo Role of IKKb/NF-kB Signaling Pathway in the Heart
IKKb/NF-kB 信号通路在心脏中的体内作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[彦惣俊吾, 他]
通讯作者:
他
DOI:
10.1016/j.yjmcc.2008.09.714
发表时间:
2008-10
期刊:
Journal of molecular and cellular cardiology
影响因子:
5
作者:
[S. Omiya;S. Hikoso;Y. Imanishi;Atsuhiro Saito;O. Yamaguchi;Toshihiro Takeda;Isamu Mizote;T. Oka;Manabu Taneike;Yuko Nakano;Y. Matsumura;K. Nishida;Y. Sawa;M. Hori;K. Otsu]
通讯作者:
S. Omiya;S. Hikoso;Y. Imanishi;Atsuhiro Saito;O. Yamaguchi;Toshihiro Takeda;Isamu Mizote;T. Oka;Manabu Taneike;Yuko Nakano;Y. Matsumura;K. Nishida;Y. Sawa;M. Hori;K. Otsu
The IκB kinase β/NF-κB signaling pathway protects the heart from hemodynamic stress mediated through the regulation of MnSOD expression
IκB 激酶 β/NF-κB 信号通路通过调节 MnSOD 表达来保护心脏免受血流动力学应激
DOI:
--
发表时间:
2009
期刊:
Circulation Research 105
影响因子:
--
作者:
[彦惣俊吾, ほか]
通讯作者:
ほか
共 12 条
Investigation for a molecular regulatory mechanism inducing endogenous myocardial inflammation
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批准号:18H02807
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
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财政年份:2018
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负责人:OTSU Kinya
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依托单位:
Integrated analyses of mitochondria degradation system as a novel therapeutic target of heart failure
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批准号:15H04822
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.4万
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财政年份:2015
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负责人:OTSU Kinya
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依托单位:
Elucidation of molecular mechanisms underlying cell death in heart failure
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批准号:19390214
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
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财政年份:2007
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负责人:OTSU Kinya
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依托单位:
Molecular Mechanism for Excitation-contraction Coupling in Heart and its Pathophysiological Significance
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批准号:13470145
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.56万
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财政年份:2001
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负责人:OTSU Kinya
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依托单位:
Investigation of Molecular Mechanism for Excitation-contraction Coupling in Heart
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批准号:12670664
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2000
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负责人:OTSU Kinya
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依托单位:
Treatment of heart failure by modulating Ca signaling protein gene expression
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批准号:10670648
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:1998
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负责人:OTSU Kinya
-
依托单位:
海外基金