Strategy for overcoming chronic kidney disease, focusing on mineralocorticoid receptor

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We previously reported that overactivation of the mineralocorticoid receptor(MR), a receptor for aldosterone, plays a crucial role in the progression of chronic kidney disease, and identified a novel mechanism of MR activation by the small G protein Rac1. In this study, we showed that´MR activation by Rac1' participates in the renal damage of angiotensin II and salt excess model, obese diabetes model, as well as in salt-sensitive hypertension. We also demonstrated that'Rac1-mediated MR activation' contributes to the inflammatory mechanism of kidney impairment.