Homeostatic regulation of autonomous nerves system by ghrelin

生长素释放肽对自主神经系统的稳态调节

• 批准号: 21390287
• 负责人: KOJIMA Masayasu
• 金额: $ 11.48万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390287/
• 关键词: グレリン; 自律神経; 体温調節; トーパー; 脂肪酸転移酵素; ノックアウトマウス; 褐色脂肪組織; 日内冬眠; 血圧; 体温; 消化管運動

Ghrelin decreases body temperature. In a hot condition, ghrelin production in stomach is stimulated and plasma ghrelin concentration is increased in mice. In addition, ghrelin KO mice shows high mortality rate in a hot condition, suggesting that these mice lack normal regulatory mechanism of body temperature. Small animals like mice show torpor(daily hibernation) induction after long term food deprivation. In torpor state, they show low body temperature and decrease of activity. However, ghrelin KO mice do not show torpor induction and suppression of energy. Thus, ghrelin is a survival hormone necessary to suppress metabolism and activity.

生长激素释放素可降低体温。在高温条件下，小鼠胃内Ghrelin的产生受到刺激，血浆Ghrelin浓度升高。此外，ghrelin KO小鼠在高温条件下表现出很高的死亡率，这表明这些小鼠缺乏正常的体温调节机制。像老鼠这样的小动物在长期缺乏食物后表现出麻木(每日冬眠)诱导。在麻木状态下，它们表现为体温降低和活动量减少。然而，Ghrelin KO小鼠没有表现出麻木诱导和能量抑制。因此，Ghrelin是一种抑制新陈代谢和活动所必需的生存荷尔蒙。

项目成果

Effects ofamino acids infused into the vein onghrelin induced GH, insulin andglucagon secretion in lactating cows

静脉注射氨基酸对泌乳牛GH、胰岛素和胰高血糖素分泌的影响

• 发表时间: 2011
• 期刊: Animal Science Journal 82
• 作者: Fukumori R;Sugino T;et al.
• 通讯作者: et al.

グレリンと体温調節・肥満

生长素释放肽和体温调节/肥胖

• 发表时间: 2010
• 作者: Takamatsu;H.;Espinoza;J;L.;Lu;X.;Qi;Z.;Okawa;K.;Nakao;S.;児島将康
• 通讯作者: 児島将康

Effects of calcium salts of long-chain fatty acids and rumen-protected methionine on plasma concentrations of ghrelin, glucagon-like peptide-1 (7 to 36) amide and pancreatic hormones in lactating cows.

长链脂肪酸钙盐和瘤胃保护蛋氨酸对泌乳牛生长素释放肽、胰高血糖素样肽-1（7至36）酰胺和胰腺激素血浆浓度的影响。

• DOI: 10.1016/j.domaniend.2011.09.005
• 发表时间: 2012
• 期刊: Domestic Animal Endocrinology
• 影响因子: 2.1
• 作者: Qi;Z.-D.;Saito;T.;et al.;Nghia Nguyen Do Trong;岩山祐己;Fukumori R
• 通讯作者: Fukumori R

Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid.

• DOI: 10.1093/jb/mvp112
• 发表时间: 2009-11
• 期刊: Journal of biochemistry
• 影响因子: 2.7
• 作者: Tomoko Takahashi;T. Ida;Takahiro Sato;Yoshiki Nakashima;Yuki Nakamura;A. Tsuji;M. Kojima

Regional distribution and the dynamics of n-decanoyl ghrelin, another acyl-form of ghrelin, upon fasting in rodents

正癸酰生长素释放肽（生长素释放肽的另一种酰基形式）在啮齿类动物禁食后的区域分布和动态

• 发表时间: 2009
• 期刊: Regul Pept
• 作者: Hiejima H;Nishi Y;Hosoda H;Yoh J;Mifune H;Satou M;Sugimoto H;Chiba S;Kawahara Y;Tanaka E;Yoshimatsu H;Uchimura N;Kangawa K;Kojima M
• 通讯作者: Kojima M