Development of amyloid^<13> C-MR imaging of the brain at 7T

本研究的目的是探索碳-13(^&lt；13&gt；C)磁共振成像(^&lt；13&gt；C-MRI)在7T阿尔茨海默病模型小鼠中描绘^&lt；13&gt；C标记淀粉样蛋白结合物质的可行性。虽然我们成功地制备了β&lt；13&gt；C标记的淀粉样蛋白结合材料，但该材料的水溶性较低。我们试着解决这些材料。给模型鼠注射这些材料后，进行脑部C-13磁共振成像。虽然观察到脑内的高信号区，但MR与组织病理学的表现有一些差异。需要进一步的研究来阐明13&gt；C-MRI的可行性。

The purpose of this study was to explore the feasibility of carbon-13(^<13> C) magnetic resonance imaging(^<13> C-MRI) to depict^<13> C-labeled amyloid-binding materials in model mice for Alzheimer dementia at 7T. Although we succeeded in producing^<13> C-labeled amyloid-binding materials, water solubility of the materials was low. We tried to solve the materials. After administration of the materials to the model mice, C-13 MR imaging of the brain was performed. Although the area of high signal in the brain was observed, there were some discrepancies between the MR and histopathologic findings. Further investigation is needed to clarify the feasibility of^<13> C-MRI.