Development of amyloid^<13> C-MR imaging of the brain at 7T

7T 大脑淀粉样蛋白^13C-MR 成像的发展

• 批准号: 21390349
• 负责人: HIRAI Toshinori
• 金额: $ 5.57万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390349/
• 关键词: 脳・神経; 認知症; 神経科学; MRI; アミロイドβ; 炭素13; 炭素13含有化合物; 炭素13MRI; アルツハイマー病; 脳アミロイド; 超高磁場MRI

The purpose of this study was to explore the feasibility of carbon-13(^<13> C) magnetic resonance imaging(^<13> C-MRI) to depict^<13> C-labeled amyloid-binding materials in model mice for Alzheimer dementia at 7T. Although we succeeded in producing^<13> C-labeled amyloid-binding materials, water solubility of the materials was low. We tried to solve the materials. After administration of the materials to the model mice, C-13 MR imaging of the brain was performed. Although the area of high signal in the brain was observed, there were some discrepancies between the MR and histopathologic findings. Further investigation is needed to clarify the feasibility of^<13> C-MRI.

本研究的目的是探讨在7 T条件下利用~（13）<13>C磁共振成像（~（13）<13>C-MRI）对<13>阿尔茨海默病模型小鼠脑内~（13）C标记的淀粉样蛋白结合物质进行成像的可行性。虽然我们成功地制备了13 <13>C-标记的淀粉样蛋白结合材料，但材料的水溶性低。我们试图解决材料问题。将材料给予模型小鼠后，进行脑的C-13 MR成像。虽然在脑内观察到高信号区，但MR和组织病理学结果之间存在一些差异。需要进一步的研究来阐明^ C-MRI的可行性<13>。