Development of DOI detectors by the use of new semiconductor based photo-detectors and their application to wearable PET systems

使用新型半导体光电探测器开发 DOI 探测器及其在可穿戴 PET 系统中的应用

• 批准号: 21390351
• 负责人: YAMAMOTO Seiichi
• 金额: $ 11.4万
• 依托单位: Kobe City College of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390351/
• 关键词: PET; 高分解能; 高感度; 分子イメージング; 光センサー; ウエアラブル; シリコンPM; 半導体; PET/MRI; 相互影響; シリコンフォトマル; LGSO; DOI; 波形解析; Si-PM; 発光減衰時間

Geiger-mode avalanche photodiode(Si-PM) is a promising photodetector for PET, especially for use in a magnetic resonance imaging(MRI) system because it has high gain and is less sensitive to static magnetic field. We developed a Si-PM based depth-of-interaction(DOI) PET system for small animals. Hamamatsu 4x4 Si-PM arrays(S11065-025P) were used for its detector blocks. Two types of LGSO scintillator of 0.75 mol% Ce(decay time :～ 45ns : 1.1mm x 1.2mm x 5mm) and 0.025 mol% Ce(decay time :～ 31ns : 1.1mm x 1.2mm x 6mm) were optically coupled in the DOI direction to form a DOI detector, arranged in 11 x 9 matrix, and optically coupled to the Si-PM array. Pulse shape analysis was used for the DOI detection of these two types of LGSOs. Sixteen detector blocks were ar-ranged in a 68mm diameter ring to form the PET system. Spatial resolution was 1.6mm FWHM and sensitivity was 0.6% at the center of the field-of-view. High resolution mouse and rat images were successfully obtained using the PET system. Simultaneous imaging with MRI was possible with some loss of the signal to noise ratio(S/N).

盖革模式雪崩光电二极管（Geiger-mode avalanche photodiode，Si-PM）具有增益高、对静磁场不敏感等优点，是一种很有前途的PET光电探测器，特别适用于磁共振成像（MRI）系统。我们开发了一种基于硅-PM的小动物相互作用深度（DOI）PET系统。Hamamatsu 4x 4 Si-PM阵列（S11065- 025 P）用于其探测器块。两种类型的LGSO闪烁体0.75mol%Ce（衰减时间：~ 45 ns：1.1mm x 1.2mm x 5 mm）和0.025mol%Ce（衰减时间：~ 31 ns：1.1mm x 1.2mm x 6 mm）在DOI方向上光学耦合以形成DOI检测器，其以11 x 9矩阵布置，并且光学耦合到Si-PM阵列。脉冲形状分析用于这两种类型的LGSO的DOI检测。16个探测器块排列在直径为68 mm的环中以形成PET系统。空间分辨率为1.6mm FWHM，视场中心灵敏度为0.6%。使用PET系统成功地获得了高分辨率的小鼠和大鼠图像。与MRI同时成像是可能的，但信噪比（S/N）有所损失。

项目成果

High resolution coincidence imaging systems using Si-PM based LGSO block detectors

使用基于 Si-PM 的 LGSO 块探测器的高分辨率符合成像系统

• 发表时间: 2011
• 作者: S. Yamamoto;T. Watabe;H. Watabe;Y. Kanai;E. Shimosegawa;J. Hatazawa
• 通讯作者: J. Hatazawa

光ファイバー型超高分解能PET/MRI一体型装置の開発とSi-PM-PET/MRI装置との比較

光纤式超高分辨率PET/MRI一体化装置的研制及与Si-PM-PET/MRI装置的比较

• 发表时间: 2011
• 作者: Nakamura M;Tokura Y;山下有紀;山本誠一
• 通讯作者: 山本誠一

Development of a high-resolution Si-PM-based gamma camera system

• DOI: 10.1088/0031-9155/56/23/014
• 发表时间: 2011-12
• 期刊: Physics in Medicine & Biology
• 影响因子: 3.5
• 作者: S. Yamamoto;H. Watabe;Y. Kanai;M. Imaizumi;T. Watabe;E. Shimosegawa;J. Hatazawa

放射線検出器

辐射探测器

• 发表时间: 2011

:Comparison between Si-PM based PET and optical fiber based PET for integrated PET/MRI systems

：用于集成 PET/MRI 系统的基于 Si-PM 的 PET 和基于光纤的 PET 之间的比较

• 发表时间: 2010
• 作者: Kobayashi K;Okamo Y;Inoue H;Usui T,Ihara M;Kawamata J;Miki Y;Mimori T,Tomimoto H;Takahashi R;S.Yamamoto
• 通讯作者: S.Yamamoto