Imaging of neuroimmunoreactlve response-Multilateral validation uslng newly developed PBR ligands for positron emlssion computed tomography
Imaging of neuroimmunoreactlve response-Multilateral validation uslng newly developed PBR ligands for positron emlssion computed tomography
批准号:
21390350
负责人:
TOYAMA Hiroshi
金额:
$11.73万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Ncuro-reccpt on(peripheral benzodiazepine receptor : PBR/translocat or prat ein : TSPO) positron emission CT(PET) imaging and histological findings were compared in rat neuro-inflammat ion model under lipopolysaccharide(LPS) administration to ampli ry the inF1anmat. ion i n raperi onea 1 ly. Increased bindings of neuro-receptor(PBR/TSPO) PET imaging were shown under cytotoxic damage, act ivated gl i a cell(mi croglia) and increased expression of inflammatory cytokines. These results suggest. that. increased PBR/TSPO binding by PET appears a promising for early diagnosis of neuro-degenerative disorders.
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脳核医学の基礎と臨床:基礎編
核脑医学基础与临床实践:基础版
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Sai A, Nishida N, Jogo A, Sogawa E, Hamamoto S, Cho H, Yamamoto A, Takeshita T, Sakai Y, Matsuoka T, Miki Y., 外山宏]
通讯作者:
外山宏
小動物のインビボ分子イメージング(ランチョンセミナー)
小动物体内分子成像(午餐研讨会)
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Noda T, et al, 外山宏]
通讯作者:
外山宏
末梢性ベンゾジァゼピン受容体/輸送蛋白(18kDa) PETによる脳内活性化ミクログリアの評価-ラットLPS腹腔内投与と毒性転換との関係-
外周苯二氮卓受体/转运蛋白 (18kDa) 通过 PET 评估大脑中活化的小胶质细胞 - 大鼠 LPS 腹膜内给药与毒性转化之间的关系 -
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[野村昌彦, 外山宏, 太田誠一朗, 片田和広, 籏野健太郎, 山田貴史, 伊藤健吾, 鈴木弘美, 澤田誠]
通讯作者:
澤田誠
小動物における定量的画像解析
小动物的定量图像分析
DOI:
--
发表时间:
2010
期刊:
脳循環代謝
影响因子:
--
作者:
[外山宏, 籏野健太郎, 鈴木弘美, 工藤元, 野村昌彦, 山田貴史, 木村裕一, 市瀬正則, 澤田誠]
通讯作者:
澤田誠
Two activated stage of microglia and PET imaging of peripheral benzodiazepine receptors with[^<11>C]PK11195 in rats
大鼠小胶质细胞的两个激活阶段和[^11C]PK11195外周苯二氮卓受体的PET成像
DOI:
--
发表时间:
2010
期刊:
Ann Nucl Med 24
影响因子:
--
作者:
[加藤元博, 他, Ito F]
通讯作者:
Ito F
共 33 条
Differences of functional role of segment lower limb exercise and attention in automatization of lower limb exercise
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批准号:26350814
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2014
-
负责人:TOYAMA Hiroshi
-
依托单位:
Basic research of molecular imaging for early diagnosis of Alzheimer's disease
-
批准号:18591369
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.47万
-
财政年份:2006
-
负责人:TOYAMA Hiroshi
-
依托单位:
Simultaneous control of dynamic standing posture on an oscillating platform and the upper limb movement in adults and children
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批准号:15500407
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:2003
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负责人:TOYAMA Hiroshi
-
依托单位:
Changes in control of eye movement and upper limb movement with automatization of postural control during floor vibration
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批准号:12680020
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.73万
-
财政年份:2000
-
负责人:TOYAMA Hiroshi
-
依托单位:
High beta improvement and current drive in spherical tokamaks by neutral particle Injection
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批准号:09480108
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.23万
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财政年份:1997
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负责人:TOYAMA Hiroshi
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依托单位:
Fuel injector for spherical tokamak using helicon wave
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批准号:09558062
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.49万
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财政年份:1997
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负责人:TOYAMA Hiroshi
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依托单位:
Investigation of Plasma Confirement of a Spherical Tokamak
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批准号:05402066
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项目类别:Grant-in-Aid for General Scientific Research (A)
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资助金额:$26.43万
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财政年份:1993
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负责人:TOYAMA Hiroshi
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依托单位:
海外基金