A novel method for inhibiting cancer metastasis and invasion by regulating the Lin7C-CASK-βcatenin-network.

本研究旨在通过激活Lin7C-CASK-βcatenin （LCB）通路，探索一种抑制口腔鳞状细胞癌（OSCC）侵袭转移的新方法。在lin7c过表达的OSCC细胞中，CASK和βcatenin水平显著高于mock转染的细胞。此外，我们通过独创性途径分析在LCB途径上游的一些分子中发现了HTR2C。我们证明了特异性HTR2C抑制剂与LCB通路密切相关，因此可能是癌症侵袭和转移的治疗工具。

The aim of this study was to develop a new method of inhibiting the invasion and metastasis of oral squamous cell carcinoma (OSCC) through the activating Lin7C-CASK-βcatenin (LCB) pathway. In Lin7C-overexpressed OSCC cells, CASK andβcatenin levels are significantly higher than that in Mock-transfected cells. In addition, we identified HTR2C in some molecules of upstream of LCB pathway by the Ingenuity Pathway Analysis. We demonstrated that the specific HTR2C inhibitor closely related to LCB pathway, and therefore might be a therapeutic tool for cancer invasion and metastasis.