Study of oncolytic virotherapy for oral cancer
Study of oncolytic virotherapy for oral cancer
批准号:
21390536
负责人:
YURA Yoshiaki
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Oncolytic virotherapy has been developed to destroy tumor cells by the cytopathic effect of virus vectors. In the present study, we produced a recombinant herpes simplex virus type 1(HSV-1) RH2 using R849 with LacZ gene at the deleted site of neurovirulentγ_1 34. 5 gene and strain HF with fusogenic ability. Nucleotide sequences of RH2 were determined with Genome Sequencer FLX. RH2 induced large syncytia in squamous cell carcinoma(SCC) cells and was deficient of neurovirulent gene. It can be used as a vector for the treatment of brain tumor as well as oral SCC
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新規融合性単純ヘルペスウイルス1型Rh2の遺伝子構造と腫瘍内増殖様式の検討
新型融合单纯疱疹病毒1型Rh2的遗传结构和瘤内生长模式研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ozawa S, Kato Y, Kubota E, Hata R, 高橋元]
通讯作者:
高橋元
活性酸素によるendonuclease Gを介した細胞死の誘導
活性氧通过核酸内切酶 G 诱导细胞死亡
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Matsumoto, S., et al., 若林健]
通讯作者:
若林健
GGTase I阻害剤が口腔扁平上皮癌細胞の増殖ならびに遊走能に及ぼす影響
GGTase I抑制剂对口腔鳞癌细胞增殖和迁移能力的影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[三木哲英, 濱田正和, 赤垣俊輔, 新谷素子, 野田隆之, 青田桂子, 岩井聡一, 由良義明]
通讯作者:
由良義明
口腔外科学 (第3版)
口腔外科(第三版)
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[林堂安貴, 他 (白砂兼光, 古郷幹彦 編)]
通讯作者:
古郷幹彦 編)
Induction of multi-nucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy
突变的 p53 硼中子捕获疗法在口腔鳞状细胞癌组织中诱导多核
DOI:
--
发表时间:
2011
期刊:
Int. J. Radiat. Biol
影响因子:
--
作者:
[Tsuruta T, Inazawa J, et al, Y. Fuji t a,N. Yamamoto,1. Kato,S. lwai,K. Ono,Y. Sakurai,K. Ohni5hi,Y. Yura]
通讯作者:
Y. Fuji t a,N. Yamamoto,1. Kato,S. lwai,K. Ono,Y. Sakurai,K. Ohni5hi,Y. Yura
共 48 条
Boron neutron capture therapy in combination with sonoporation
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批准号:23659944
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2011
-
负责人:YURA Yoshiaki
-
依托单位:
Study of gene therapy for lymph node metastasis of oral squamous cell carcinoma
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批准号:16390586
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.91万
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财政年份:2004
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负责人:YURA Yoshiaki
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依托单位:
Gene therapy for oral squamous cell carcinoma with herpes simplex virus vector
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批准号:13470432
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.42万
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财政年份:2001
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负责人:YURA Yoshiaki
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依托单位:
Chemotherapy of salivary gland carcinomas with tyrosine kinase inhibitors
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批准号:11671869
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.43万
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财政年份:1999
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负责人:YURA Yoshiaki
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依托单位:
Gene therapy of salivary gland carcinoma with virus vector
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批准号:10557192
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$4.42万
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财政年份:1998
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负责人:YURA Yoshiaki
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依托单位:
The effects of bryostatin on the grwoth of salivary gland tumor cells and the replication of herpes simplex virus
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批准号:09672052
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:1997
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负责人:YURA Yoshiaki
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依托单位:
Studies of latent infection of herpes simplex virus and protein kinase
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批准号:07672178
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.47万
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财政年份:1995
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负责人:YURA Yoshiaki
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依托单位:
The Development of Model System for Maxillary Cancer
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批准号:04807146
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.22万
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财政年份:1992
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负责人:YURA Yoshiaki
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依托单位:
Effect of Salivary Epidermal Growth Factor on Hamster Oral Carcinogenesis
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批准号:01571096
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1989
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负责人:YURA Yoshiaki
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依托单位:
海外基金