Molecular basis of neuron-specific, activity-dependent regulation of the plasticity-related gene Arc

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The neuronal immediate-early gene Arc, which plays critical roles in long-term synaptic plasticity and long-term memory formation, is dynamically regulated by neuronal activities in the brain. Through this study, we have determined several genomic regulatory elements in the Arc promoter, and have identified transcription factors that contribute to activity-dependent expression. We further uncovered a novel mechanism by which Arc protein is localized and thus regulates glutamate receptor trafficking at synapses.