Neural mechanisms of behavior selection by extracting valuable information from complex and fluctuated environment

从复杂波动的环境中提取有价值信息的行为选择的神经机制

• 批准号: 21500310
• 负责人: MORIMOTO Takako
• 金额: $ 2.91万
• 依托单位: Tokyo University of Pharmacy and Life Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500310/
• 关键词: 行動神経科学; ゆらぎ; ショウジョウバエ; 視覚; 視運動反応; 行動選択; 忌避物質; 誘引物質; 行動決定

Environment surrounding us is not simple and static. In fact, it is complex, often fluctuated, ambiguous, and includes unreliable information. How do animals extract valuable information from such ambiguous environment and decide an appropriate behavior? To solve this issue, we have studied the behavior of Drosophila melanogaster responding to ambiguous stimulations. We found that visual system in adult Drosophila showed noise robustness revealing from the optomotor response to the visual stimulus including noise. Moreover, we established the experimental system to study the mechanisms of decision making under the complex situation by using Drosophila larvae.

我们周围的环境并不是简单和静态的。事实上，它是复杂的、经常波动的、模棱两可的，并且包含不可靠的信息。动物如何从这种模棱两可的环境中提取有价值的信息，并决定适当的行为？为了解决这个问题，我们研究了果蝇对模糊刺激的反应行为。我们发现，成年果蝇的视觉系统对包括噪声在内的视觉刺激的视觉运动反应显示出噪声的稳健性。此外，我们以果蝇幼虫为研究对象，建立了研究复杂情境下果蝇决策机制的实验系统。

项目成果

ハエ視覚系に存在する再帰的な神経回路の理論解析:回転刺激に対する応答特性

果蝇视觉系统递归神经回路的理论分析：对旋转刺激的反应特性

• 发表时间: 2012
• 期刊: 信学技報
• 作者: 鈴木力憲;森本高子;宮川博義;青西亨
• 通讯作者: 青西亨

Selection of behaviors and segmental coordination during larval locomotion is disrupted by nuclear polyglutamine inclusions in a new Drosophila Huntington's disease-like model

在新的果蝇亨廷顿病样模型中，幼虫运动过程中的行为选择和节段协调被核聚谷氨酰胺内含物破坏

• 发表时间: 2010
• 期刊: J. Neurogenet
• 作者: Nishimura;Y.;Yalgin;C.;Akimoto;S.;Doumanis;J.;Sasajima;R.;Nukina;N.;Miyakawa;H.;Moore;A.W. & Morimoto;T
• 通讯作者: T

Functional analysis of Centaurin gamma1A in the synaptic transmission

Centaurin gamma1A 在突触传递中的功能分析

• 发表时间: 2011
• 作者: Mizuho Homma;Sun Nagashima;Toshifumi Fukuda;Shigeru Yanagi;Hiroyoshi Miyakawa;and Takako Morimoto
• 通讯作者: and Takako Morimoto

Establishment of an experimental system to study the mechanisms of motion detection in Drosophila melanogaster

果蝇运动检测机制实验系统的建立

• 发表时间: 2009
• 作者: Takuya Miyamoto;Akiko Kikuchi;Toshiaki Ohta;Azusa Kmikouchi;Hiroyoshi Miyakawa;and Takako Morimoto
• 通讯作者: and Takako Morimoto

Subunit-specific and homeostatic regulation of glutamate receptor localization by CaMKII in Drosophila neurosmuscular junctions

果蝇神经肌肉接头中 CaMKII 对谷氨酸受体定位的亚基特异性和稳态调节

• 发表时间: 2010
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: Morimoto T.;Nobechi M.;Komatsu A.;Miyakawa H.;and Nose;A.
• 通讯作者: A.