Regulation of axonal transport by local interaction with myelin

通过与髓磷脂的局部相互作用调节轴突运输

• 批准号: 21500355
• 负责人: BABA Hiroko
• 金额: $ 2.91万
• 依托单位: Tokyo University of Pharmacy and Life Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500355/
• 关键词: グリア細胞; 神経科学; 脳・神経; 髄鞘; 神経軸索; グリア; 軸索輸送

In order to elucidate the role of myelin on axonal transport, immunohistological and biochemical analyses were performed in the central and peripheral nervous systems of myelin mutant mice. In these mice, paranodal axo-glial junctions(AGJ) were disrupted but compact myelin was preserved. The present results demonstrated that disruption of AGJ caused local axonal swellings containing various axonal components and changes of axonal transport-related molecules. Involvement of local calcium change was suggested. Focal axonal swellings were first observed at early stage of myelination and progressive with age. Axonal degeneration became more prominent in aged mice. Thus, the axo-glial interaction at the paranode is important for local axonal homeostasis.

为了阐明髓鞘对轴突运输的作用，在髓鞘突变小鼠的中枢和外周神经系统中进行免疫组织化学和生物化学分析。在这些小鼠中，旁结轴-胶质细胞连接（AGJ）被破坏，但致密的髓鞘被保留。本研究结果表明，AGJ的破坏引起局部轴突sites包含各种轴突成分和轴突运输相关分子的变化。局部钙变化的参与建议。局灶性轴索硬化最早见于髓鞘形成的早期，并随年龄增长而发展。老年小鼠轴突变性更加明显。因此，在旁阳极的轴神经胶质细胞的相互作用是重要的局部轴突稳态。

项目成果

Disruption of axo-glial interaction causes focal damages in cerebellar Purkinje neurons

轴-神经胶质相互作用的破坏导致小脑浦肯野神经元的局灶性损伤

• 发表时间: 2011
• 作者: Tomoko Ishibashi;Hiroko Baba
• 通讯作者: Hiroko Baba

Disruption of the axo-glial interaction causes focal axonal damages in cerebellar Purkinje neurons

轴突-胶质细胞相互作用的破坏导致小脑浦肯野神经元的局灶性轴突损伤

• 发表时间: 2011
• 作者: 柳田俊彦;根本隆行;佐藤伸矢;吉川教恵;丸田豊明;村上学;Hiroko Baba
• 通讯作者: Hiroko Baba

Disruption of paranodal axo-glial junctions causes alteration of axonal transport in the PNS

节旁轴神经胶质连接的破坏导致三七总皂苷中轴突运输的改变

• 发表时间: 2009
• 作者: Akiko Kodama;et al
• 通讯作者: et al

パラノーダルジャンクション形成不全時における小脳プルキンエ細胞の変化

结旁连接发育不全时小脑浦肯野细胞的变化

• 发表时间: 2011
• 作者: 石橋智子;馬場広子
• 通讯作者: 馬場広子

Disruption of the axo-glial interaction causes focal axonal damages in cerebellar Purkinje neurons.

轴突-胶质细胞相互作用的破坏会导致小脑浦肯野神经元的局灶性轴突损伤。

• 发表时间: 2010
• 作者: 根本隆行;柳田俊彦;村上学;吉田眞理;椙村益久;Hiroko Baba
• 通讯作者: Hiroko Baba