Mechanism of the inhibition of cancer cell growth using low voltage electric pulses

低压电脉冲抑制癌细胞生长的机制

• 批准号: 21500402
• 负责人: MATSUKI Noriaki
• 金额: $ 2.91万
• 依托单位: Okayama University of Science (2010-2011)Tohoku University (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500402/
• 关键词: エレクトロポレーション; アポトーシス; 低電圧電気パルス; カスパーゼ; 膜透過性

We previously reported that cancer cell apoptosis was induced through electroporation(membrane pore formation) with the application of low voltage electric pulses(LVEPs). In this study, we reported about the apoptosis mechanism of cancer cells that LVEPs impose cell stress and induce apoptosis through caspases activation of both cell death receptor and mitochondrial pathways following intrcellular Ca++elevation. A series of our studies suggest that LVEPs which might be mild damage to the patients could take place of high voltage electrochemtherapy which is studied as a new anti-cancer therapy.

我们之前报道过，通过应用低压电脉冲（LVEP）的电穿孔（膜孔形成）诱导癌细胞凋亡。在这项研究中，我们报道了癌细胞的凋亡机制，即LVEPs通过细胞内Ca++升高后激活细胞死亡受体和线粒体途径的半胱天冬酶施加细胞应激并诱导细胞凋亡。我们的一系列研究表明，对患者损伤较轻的LVEP可以替代高压电化学疗法，作为一种新的抗癌疗法进行研究。

项目成果

Activation of caspases and apotosis in response to low-voltage electric pulses

响应低压电脉冲激活半胱天冬酶和凋亡

• 发表时间: 2010
• 期刊: Oncology Reports
• 影响因子: 4.2
• 作者: N. Matsuki;M. Takeda;T. Ishikawa;T. Hayasaka;Y. Imai;and T. Yamaguchi
• 通讯作者: and T. Yamaguchi

Activation of caspases and apoptosis in response to low-voltage electric pulses

• DOI: 10.3892/or_00000780
• 发表时间: 2010-05-01
• 期刊: ONCOLOGY REPORTS
• 影响因子: 4.2
• 作者: Matsuki, Noriaki;Takeda, Motohiro;Yamaguchi, Takami
• 通讯作者: Yamaguchi, Takami