Development andApplication of Methodology of Magnetic Resonance Measurement of Hyperpolarized Noble Gas Contributable to Physiological Diagnosis.

本文介绍了一种连续流动式超极化氙产生装置，它能提高氙的灵敏度。在本研究中已成功开发了20，000次。采用HPV-MRI进行肺功能成像，建立了同时进行肺功能成像和脑弛豫率测量的方法，并研究了COPD小鼠模型肺功能成像和脑弛豫率测量之间的关系。结果，肺功能的局部异常可以被可视化，并且与健康小鼠相比，T1 i-1增加。T1 i-1与肺内气体交换%呈负相关。

The continuous-flow type apparatus for producing hyperpolarized xenon (HP Xe) which can improve the sensitivity by ca. 20,000 times has been successfully developed in the present study. Adopting HP Xe MRI to the lungimaging, we developed the methodology to simultaneously perform the pulmonary functional imaging and the relaxation rate measurement in the brain of HP Xe and investigated the relationship between the two functions of the mouse models of COPD. As a result, the regional abnormalities of the pulmonary funation could be visualized, and the T1i-1was increased compared to that of the healthy mouse. A negative correlation between the T1i-1and the % gas-exchange in the lung was observed.