Development of artificial articular cartilage with a region selective osteoconduction using a nanotechnology

研究了聚乙烯醇水凝胶（PVM-H）和复合骨软骨支架（COD）组成的部分可替代人工关节软骨。COD可替代天然关节软骨的局部损伤。研究了COD与骨组织之间的长期固定技术。COD表面必须具有生物惰性功能。另一方面，在COD和活骨之间的边界中，骨传导粘附是必要的。也就是说，部分选择性粘附功能（PSAF）进行了研究。我们将PVA-H与几种磷灰石薄膜结合，在COD中实现了PSAF。研究了PVA-Hs及其薄膜的生物相容性、机械强度和材料性能。

We studied on a partial repalcementable artificial articular cartilage, composed of polyvinyl alcohol hydrogel(PVM-H), or a composite osteo-chondral device(COD). The COD is able to replace the local lesion of natural articular cartilage. A long-term fixation technique between the COD and osseous tissues was studied. The COD surface must have bio-inert function. On the other hand, in the boundary between the COD and living bone, the osteoconductive adhesion is necessary. That is, the partial selective adhesion function(PSAF) was investigated. We have materialized PSAF in the COD by integration the PVA-H and several kinds of apatite thin film. Biocompatibility, mechanical strength and material property of both PVA-Hs and the thin films were studied.