A search for peptides binding to assembly of amyloid-beta by novel fluorescence-screening

许多荧光染料通过在各种波长的光下激发而发荧光，这些荧光染料连接到各种肽，并且这些肽用作肽库。将这些肽与淀粉样蛋白-β的组装体在水溶液中混合。β淀粉样蛋白被认为是阿尔茨海默病的病原体。在这些荧光染料修饰的肽中，通过这些荧光染料修饰的肽的荧光图案发现与淀粉样蛋白-β强烈结合的肽。

Many fluorescent dyes that fluoresces by exciting at light of various wavelength were connected to various peptides and these peptides were used as peptide library. These peptides were mixed with assembly of amyloid-beta in aqueous solution. Amyloid-beta is thought to be a causative agent of Alzheimer's disease. Of these fluorescent dye-modified peptides, the peptide bound to amyloid-beta strongly was found by fluorescence patterns of these fluorescent dyes modified to peptides.