Analysis of the basement membrane function and application to the artificial basement membrane

对合成多肽对层粘连蛋白的分子分离进行了测试，发现可以用层粘连蛋白活性多肽来分析和模拟层粘连蛋白的生物学活性。层粘连蛋白衍生的多肽-多糖层粘连蛋白具有多种生物活性，这些活性可以通过改变多肽-多糖的生物学和物理性质来控制。多肽和多糖的组合提供了具有不同生物学活性的独特的多肽基质，这表明这些结构对于细胞类型特定的生物材料是有用的。

Molecular dissection of laminin by synthetic peptides was tested and found that biological activities of laminin could analyze and mimic using laminin active peptides. The laminin derived mixed peptides-polysaccharides exhibited many biological activities and these activities can control by changing the biological and physical properties of peptides-polysaccharides. Combinations of the peptides and the polysaccharides provide unique peptide-matrices with different biological activities, suggesting that these constructs are useful for cell type specific biomaterials.