Investigation of signal generation mechanism in ultrasound-modulated optical measurement for optical scattering medium

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Ultrasound-modulated optical tomography has the possibility of detecting optical structures with highly spatial resolution under deep inside optical scattering medium. In this research, generation mechanism of the ultrasound-modulated optical signals was investigated to retrieve quantitative signals from the modulation signals for clinical applications. Using a reflective ultrasound-modulated optical spectroscopic system, the speckle patterns formed by the multiple scattering light was obtained and the wavelength dependence of irradiating beam by Monte-Carlo simulation revealed the similar dependence for the experimental results.