Sensing system to detect magnetic nano-particles for magnetic drug delivery

检测用于磁性药物输送的磁性纳米颗粒的传感系统

• 批准号: 21760313
• 负责人: HATSUKADE Yoshimi
• 金额: $ 2.83万
• 依托单位: Toyohashi University of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21760313/
• 关键词: 計測システム; ドラッグデリバリー; 磁気的ドラッグデリバリー; 磁気ナノ微粒子; 磁気センサ; SQUID; 薬剤検出; センサアレイ; 磁気特性; SUID

In this study, we developed a sensing system using ultra-sensitive SQUID magnetic sensors to detect magnetic nano-particles as a component technology for magnetic drug delivery system (MDDS). An array of 3 channel SQUID was installed on the system, to study the magnetic characteristics of magnetic nano-particles, whose diameters were less than 100 nm. An appropriate method to magnetize and detect the magnetic nano-particles was also investigated. As a result, we found that the particles with diameter of 50 nm generated the largest magnetic signal among the tested particles, and that a dc magnetization method was best suited because this method enabled to suppress energy due to the Brownian motion and convection in ferrofluid of 3 micron litter by means of the static magnetic field, and to detect moving particles in a tube.

在本研究中，我们开发了一种利用超灵敏SQUID磁传感器检测磁性纳米颗粒的传感系统，作为磁性药物输送系统（MDDS）的组成技术。在系统上安装了一个三通道SQUID阵列，用于研究直径小于100 nm的磁性纳米颗粒的磁性特性。并对磁性纳米粒子的磁化和检测方法进行了研究。其结果是，我们发现，直径为50 nm的颗粒产生最大的磁信号之间的测试颗粒，直流磁化方法是最适合的，因为这种方法能够抑制能量由于布朗运动和对流的铁磁流体的3微米的静磁场的装置，并检测移动的颗粒在管中。

项目成果

Determination of the robustness of an HTS SQUID magnetometer covered with a superconducting film shield in an ac field

确定覆盖有超导薄膜屏蔽的 HTS SQUID 磁力计在交流场中的鲁棒性

• 发表时间: 2009
• 期刊: Supercond.Sci.Technol. Vol.22
• 作者: Y.Hatsukade;K.Hayashi;M.Takemoto;S.Tanaka
• 通讯作者: S.Tanaka

HTS-RF-SQUID Microscope For Metallic Contaminant Detection

用于金属污染物检测的 HTS-RF-SQUID 显微镜

• 发表时间: 2010
• 作者: M.Takemoto;T.Akai;Y.Kitamura;Y.Hatsukade;S.Tanaka
• 通讯作者: S.Tanaka

Liquid-State Nuclear Magnetic Resonance Measurements for Imaging using HTS-rf-SQUID in Ultra-Low Field

超低场中使用 HTS-rf-SQUID 进行液态核磁共振成像测量

• 发表时间: 2010
• 作者: S.Fukumoto;M.Hayashi;Y.Katsu;M.Suzuki;R.Morita;Y.Naganuma;Y.Hatsukade O.Snigirev;S.Tanaka
• 通讯作者: S.Tanaka

Detection of wire element breakage in power transmission line using HTS-SQUID

• DOI: 10.1016/j.physc.2009.05.086
• 发表时间: 2009-08-01
• 期刊: PHYSICA C-SUPERCONDUCTIVITY AND ITS APPLICATIONS
• 影响因子: 1.7
• 作者: Miyazaki, A.;Hatsukade, Y.;Tanaka, S.
• 通讯作者: Tanaka, S.

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