Sensing system to detect magnetic nano-particles for magnetic drug delivery

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In this study, we developed a sensing system using ultra-sensitive SQUID magnetic sensors to detect magnetic nano-particles as a component technology for magnetic drug delivery system (MDDS). An array of 3 channel SQUID was installed on the system, to study the magnetic characteristics of magnetic nano-particles, whose diameters were less than 100 nm. An appropriate method to magnetize and detect the magnetic nano-particles was also investigated. As a result, we found that the particles with diameter of 50 nm generated the largest magnetic signal among the tested particles, and that a dc magnetization method was best suited because this method enabled to suppress energy due to the Brownian motion and convection in ferrofluid of 3 micron litter by means of the static magnetic field, and to detect moving particles in a tube.