Sensing system to detect magnetic nano-particles for magnetic drug delivery

检测用于磁性药物输送的磁性纳米颗粒的传感系统

• 批准号: 21760313
• 负责人: HATSUKADE Yoshimi
• 金额: $ 2.83万
• 依托单位: Toyohashi University of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21760313/
• 关键词: 計測システム; ドラッグデリバリー; 磁気的ドラッグデリバリー; 磁気ナノ微粒子; 磁気センサ; SQUID; 薬剤検出; センサアレイ; 磁気特性; SUID

In this study, we developed a sensing system using ultra-sensitive SQUID magnetic sensors to detect magnetic nano-particles as a component technology for magnetic drug delivery system (MDDS). An array of 3 channel SQUID was installed on the system, to study the magnetic characteristics of magnetic nano-particles, whose diameters were less than 100 nm. An appropriate method to magnetize and detect the magnetic nano-particles was also investigated. As a result, we found that the particles with diameter of 50 nm generated the largest magnetic signal among the tested particles, and that a dc magnetization method was best suited because this method enabled to suppress energy due to the Brownian motion and convection in ferrofluid of 3 micron litter by means of the static magnetic field, and to detect moving particles in a tube.

在这项研究中，我们使用超敏感的鱿鱼磁性传感器开发了一个传感系统，以检测磁性纳米粒子作为磁性药物输送系统（MDDS）的组件技术。系统上安装了3通道鱿鱼的阵列，以研究磁性纳米颗粒的磁性特性，其直径小于100 nm。还研究了一种磁化和检测磁性纳米颗粒的合适方法。结果，我们发现直径为50 nm的颗粒在测试颗粒中产生了最大的磁信号，并且最适合使用DC磁化方法，因为这种方法能够抑制3微米在3微米中的Ferrofluid引起的能量，并通过静态磁场和静态磁场的移动粒子进行移动粒子。

项目成果

Biomagnetic Application using HTS-SQUID Array

使用 HTS-SQUID 阵列的生物磁应用

• 发表时间: 2010
• 作者: Y.Hatsukade;A.Karitani;M.Takemoto;T.Terui;Y.Kitamura;Y.Shinyama;S.Fukumoto;S.Tanaka
• 通讯作者: S.Tanaka

Liquid-State Nuclear Magnetic Resonance Measurements for Imaging using HTS-rf-SQUID in Ultra-Low Field

超低场中使用 HTS-rf-SQUID 进行液态核磁共振成像测量

• 发表时间: 2010
• 作者: S.Fukumoto;M.Hayashi;Y.Katsu;M.Suzuki;R.Morita;Y.Naganuma;Y.Hatsukade O.Snigirev;S.Tanaka
• 通讯作者: S.Tanaka

HTS-RF-SQUID Microscope For Metallic Contaminant Detection

用于金属污染物检测的 HTS-RF-SQUID 显微镜

• 发表时间: 2010
• 作者: M.Takemoto;T.Akai;Y.Kitamura;Y.Hatsukade;S.Tanaka
• 通讯作者: S.Tanaka

Determination of the robustness of an HTS SQUID magnetometer covered with a superconducting film shield in an ac field

确定覆盖有超导薄膜屏蔽的 HTS SQUID 磁力计在交流场中的鲁棒性

• 发表时间: 2009
• 期刊: Supercond.Sci.Technol. Vol.22
• 作者: Y.Hatsukade;K.Hayashi;M.Takemoto;S.Tanaka
• 通讯作者: S.Tanaka

Nondestructive evaluation of braided carbon fiber composites with artificial defect using HTS-SQUID gradiometer

• DOI: 10.1016/j.physc.2011.05.169
• 发表时间: 2011-11
• 期刊: Physica C-superconductivity and Its Applications
• 影响因子: 1.7
• 作者: Y. Shinyama;T. Yamaji;Y. Hatsukade;Y. Takai;M. Aly-Hassan;A. Nakai;H. Hamada;Saburo Tanaka