Development and application of instrumental analysis method for detection of pharmaceuticals and metabolites in water environment

采用LC/MS/MS成功建立了水环境中3种药物和5种代谢物同时检测的仪器分析方法，可用于水净化和废水处理过程中的现场调查。在一家污水处理厂发现了七种药物和代谢物，含量在数十至数千纳克/升之间。卡马西平及其代谢物不仅存在于原水中，而且存在于净水厂的成品水中，因此可能存在于饮用水中。

Simultaneous instrumental analysis method for detection of three pharmaceuticals and five metabolites in water environment was successfully developed by using LC/MS/MS and served for an on-site investigation in the course of water purification and that of wastewater treatment. Seven pharmaceuticals and metabolites were found in the range of tens to thousands ng/L at a wastewater treatment plant. Both carbamazepine and its metabolite were found not only in raw water but also in finished water at a water purification plant, thus, they could possibly remain in drinking water.