Highly functionalized drug-eluting stent systems controlled by combining polymers with nano-/micro-patterned diamond-like carbon(DLC) films

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The aim of this project is to develop the surface modification technique, which improve the hemocompatibility and tissue compatibility of vascular implant surface. Specifically, we designed the highly controlled new drug eluting coating by the combination of drug carrier polymer and micron-patterned diamond-like carbon(DLC) films. The main results of this project is mentioned as below, that is, 1) DLC and fluorine incorporated DLC(F-DLC) showed well compatibility with endothelial cells, then the results indicate that the DLC and F-DLC acting as platform of cells adhesion, 2) micron-patterned DLC coating well controls the drug emission from the carrier polymer and this performance is based on the piece size of micron-patterned DLC, 3) As an impregnating drug, basic fibroblast glows factor(bFGF) specifically improves the endothelial cells growth rate comparing with smooth muscle cells.