Highly functionalized drug-eluting stent systems controlled by combining polymers with nano-/micro-patterned diamond-like carbon(DLC) films
通过将聚合物与纳米/微米图案类金刚石碳 (DLC) 薄膜相结合来控制的高功能化药物洗脱支架系统
基本信息
- 批准号:21760561
- 负责人:
- 金额:$ 2.83万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Young Scientists (B)
- 财政年份:2009
- 资助国家:日本
- 起止时间:2009 至 2011
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The aim of this project is to develop the surface modification technique, which improve the hemocompatibility and tissue compatibility of vascular implant surface. Specifically, we designed the highly controlled new drug eluting coating by the combination of drug carrier polymer and micron-patterned diamond-like carbon(DLC) films. The main results of this project is mentioned as below, that is, 1) DLC and fluorine incorporated DLC(F-DLC) showed well compatibility with endothelial cells, then the results indicate that the DLC and F-DLC acting as platform of cells adhesion, 2) micron-patterned DLC coating well controls the drug emission from the carrier polymer and this performance is based on the piece size of micron-patterned DLC, 3) As an impregnating drug, basic fibroblast glows factor(bFGF) specifically improves the endothelial cells growth rate comparing with smooth muscle cells.
本课题的目的是发展表面改性技术,提高血管植入物表面的血液相容性和组织相容性。具体而言,我们设计了高度控制的新的药物洗脱涂层的药物载体聚合物和微米图案的类金刚石碳(DLC)膜的组合。本课题的主要研究结果如下:1)类金刚石和含氟类金刚石(F-DLC)与内皮细胞具有良好的相容性,表明类金刚石和含氟类金刚石作为细胞粘附的平台; 2)微米图案类金刚石涂层能够很好地控制载体聚合物的药物释放,这种性能是基于微米图案类金刚石的片尺寸,3)碱性成纤维细胞发光因子(basic fibroblast glows factor,bFGF)作为一种药物,与平滑肌细胞相比,能特异性地提高内皮细胞的生长速度。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Challenges in prevention and treatment of late stent thrombosis : Fluorine incorporated diamond-like carbon nano-coatings
预防和治疗晚期支架血栓形成的挑战:含氟类金刚石碳纳米涂层
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:田中俊輔;来田康司;三宅義和;長谷部光泉;長谷部光泉;Terumitsu Hasebe;Terumitsu Hasebe;Hasebe T;Terumitsu Hasebe
- 通讯作者:Terumitsu Hasebe
Combining polymers with diamond-like carbon (DLC) for highly functionalized materials
- DOI:10.1016/j.surfcoat.2011.02.064
- 发表时间:2011-11-15
- 期刊:
- 影响因子:5.4
- 作者:Asakawa, R.;Nagashima, S.;Hotta, A.
- 通讯作者:Hotta, A.
新しいデバイス開発2 :ステント・ステントグラフト
新器械开发2:支架和覆膜支架
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:長谷部光泉;正林康宏;吉本幸洋;永島壮;笠井ルミ子;粕谷秀輔;北村範子;稲岡努;寺田一志;谷下一夫;鈴木哲也
- 通讯作者:鈴木哲也
Next generation drug-eluting stent : Controlling the drug release properties of biocompatible polymer with micro-patterned non-thrombogenic carbon coatings
下一代药物洗脱支架:通过微图案非血栓形成碳涂层控制生物相容性聚合物的药物释放特性
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:来田康司;田中俊輔;三宅義和;Terumitsu Hasebe
- 通讯作者:Terumitsu Hasebe
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HASEBE Terumitsu其他文献
HASEBE Terumitsu的其他文献
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{{ truncateString('HASEBE Terumitsu', 18)}}的其他基金
Fabrication of high-radiopaque drug-eluting microbeads for transarterial chemoembolization
用于经动脉化疗栓塞的高不透射线药物洗脱微珠的制备
- 批准号:
19K22068 - 财政年份:2019
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Antithrombogenic/flexible carbon-based nano-coating for superelastic Nitinol alloy stent in peripheral arterial disease.
用于外周动脉疾病的超弹性镍钛诺合金支架的抗血栓形成/柔性碳基纳米涂层。
- 批准号:
18H01726 - 财政年份:2018
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of new aortic stent-graft materials by plasma technology that can control the surface morphology and the drug elution
利用等离子体技术开发新型主动脉覆膜支架材料,可控制表面形貌和药物洗脱
- 批准号:
15K06492 - 财政年份:2015
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of new aortic stent-graft materials by plasma technology that can control the surface morphology and the drug elution
利用等离子体技术开发新型主动脉覆膜支架材料,可控制表面形貌和药物洗脱
- 批准号:
24560860 - 财政年份:2012
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)