Molecular mechanisms of synchronous exocytosis of extracellular matrices after fertilization

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We have found that the small GTPase RAB-11 is required for cortical granule exocytosis after fertilization which delivers essential extracellular matrices. Furthermore, GFP : : RAB-11 accumulates transiently on the cortical granules during ovulation. To understand how the localization and/or activity of RAB-11 are developmentally regulated, we looked for RAB-11-binding proteins by yeast two-hybrid screening. We identified a new RAB-11-binding protein named REI-1. REI-1 is highly conserved amang metazoans, implying its fundamental role.