The roles and specificities of the regulators for small GTP-binding proteins in the regulation of neuronal cell location

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Cerebral cortex is developed particularly in mammals, and recent studies using slice culture, in vivo gene expression, knockout mice, and imaging system have elucidated the structure of neuronal circuit and developmental process in the cerebral cortex. Rho family small GTPases act as molecular switches in cells and regulate cytoskeleton to control cell migration and neurite outgrowth in cultured cells. However, their roles in the development of cerebral cortex have not yet well understood. In this study, we studied the role of RhoG in the developing mouse cerebral cortex and found that RhoG promoted neuronal progenitor cell proliferation.