Regulatory roles for the functional network of placenta on maintenance of homeostasis during pregnancy

为了阐明胎盘功能网络在正常妊娠期间维持内稳态的调节作用，我使用全基因组表达谱在分子水平上表征了怀孕小鼠的胎盘。确定代谢相关基因和新血管生成相关基因表达水平的动态变化。另一方面，在人类中，妊娠高血压综合征(PIH)被认为是由于妊娠内环境平衡的破坏而引起的。在这项研究中，我证明了我们实验室以前培育的妊娠相关高血压(PAH)小鼠表现出包括妊高征标准在内的病理状况。此外，通过评估抗高血压药物在PAH小鼠中的改善作用，我证明了阻断血管加压素II受体AT1在预防这种妊娠相关疾病方面的有效性。

To clarify the regulatory roles for the functional network of placenta on maintenance of homeostasis during normal pregnancy, I used full genome expression profiling to characterize the placenta of pregnant mice at a molecular level. The dynamic changes in the expression levels of metabolism- and neoangiogenesis-related genes were identified. On the other hand, in human, it is assumed that pregnancy-induced hypertension (PIH) is resulting from the breakdown of the pregnancy homeostasis. In this study, I showed that pregnancy-associated hypertensive (PAH) mice, which were previously generated in our laboratory, exhibited the pathological condition including the criteria of PIH. In addition, by evaluating the ameliorative properties of the antihypertensive drugs in PAH mice, I demonstrated the effectiveness of blockade of AT1, a receptor of vasopressor angiotensin II, on prevention of this pregnancy-related disease.