The study of molecular polymorphisms of glycophorin A oligomer in bovine red blood cells associated with the bovine piroplasmosis resistibility

牛红细胞血型糖蛋白A寡聚物分子多态性与牛梨形虫病抵抗力的研究

• 批准号: 21780282
• 负责人: OTSUKA Yayoi
• 金额: $ 3万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21780282/
• 关键词: 牛ピロプラズマ病; グライコフォリンA; 受容体; シアル酸; シアロ糖蛋白質; シアロ糖タンパク質

The present study demonstrated that a high-molecular weight sialoglycoprotein with apparent molecular masses >500 kDa (GPA oligomer) in bovine erythrocyte membranes consists of glycophorin A, glycophorin B, and CD58. GPA oligomers showed variety among individuals in their protein compositions, contents and sizes. Moreover, there were served different glycophorin B variants and this variation in glycophorin B species appeared to represent the blood group system F. Moreover, diversity of GPA oligomer might be involved in protozoan infectivity into bovine red cells.

本研究证明牛红细胞膜上一种表观分子质量为500 kDa的高分子唾液酸糖蛋白(GPA寡聚体)由血糖素A、血糖蛋白B和CD58组成。GPA寡聚体的蛋白质组成、含量和大小因个体而异。此外，存在不同的血糖蛋白B变异体，血糖蛋白B物种的这种变异似乎代表了F血型系统。此外，GPA寡聚体的多样性可能与原虫感染牛红细胞有关。

项目成果

The covalent modification of spectrin in red cell membranes by the lipid peroxidation product 4-hydroxy-2-nonenal

• DOI: 10.1016/j.bbrc.2009.12.121
• 发表时间: 2010-01-15
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Arashiki, Nobuto;Otsuka, Yayoi;Inaba, Mutsumi
• 通讯作者: Inaba, Mutsumi

Parallel reductions in stomatin and Na, K-ATPase through the exosomal pathway during reticulocyte maturation in dogs : stomatin as a genotypic and phenotypic marker of high K+ and low K+ red cells.

狗网织红细胞成熟过程中，stomatin 和 Na, K-ATPase 通过外泌体途径平行减少：stomatin 作为高 K 和低 K 红细胞的基因型和表型标记。

• 发表时间: 2010
• 期刊: J Vet Med Sci. 62(7)
• 作者: Komatsu T;Sato K;Otsuka Y;Arashiki N;Tanaka K;Tamahara S;Ono KI;Inaba M.
• 通讯作者: Inaba M.

Parallel reductions in stomatin and Na, K-ATPase through the exosomal pathway during reticulocyte maturation in dogs : stomatin as a genotypic and phenotypic marker of high K+ and low K+ red cells

狗网织红细胞成熟过程中，通过外泌体途径，stomatin和Na，K-ATP酶平行减少：stomatin作为高K和低K红细胞的基因型和表型标记

• 发表时间: 2010
• 期刊: Journal of Veterinary Medical Science 62
• 作者: Tomohiko Komatsu;Yayoi Otsuka;Kota Sato;Mutsumi Inaba;et al.
• 通讯作者: et al.

牛赤血球膜グライコフォリンA&B:性状と血液型抗原との関連

牛红细胞膜血型糖蛋白A&B：特性及其与血型抗原的关系

• 发表时间: 2009
• 作者: 大塚弥生;ら
• 通讯作者: ら

牛赤血球膜のグライコフォリンAとBによる高分子シアロ糖蛋白質複合体の形成

牛红细胞膜中糖蛋白 A 和 B 形成聚合唾液酸糖蛋白复合物

• 发表时间: 2009
• 作者: 大塚弥生;大村俊弥;大津航;黒木一仁;森田光夫;佐藤耕太;稲葉睦
• 通讯作者: 稲葉睦