Effect of oral tributyrin in intestinal injury

点击翻译按钮获取中文摘要

Oral tributyrin, prodrug of butyrate, increased plasma butyrate level in inferior vena cava and expression of PPARγ and apoptosis in small and large intestine. And tributyrin attenuated intestinal injury associated with lipopolysaccharide injection. The increase in pro-inflammatory cytokine TNF-α/IL-1β mRNA level, pathological changes including hemorrhage, and high mortality were improved by tributyrin. Oral tributyrin increased plasma butyrate level and attenuated intestinal injury in endotoxemic rats.