Synthetic Study of Antitumor Alkaloids Haouamines Using a Cascade Cyclization

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Formal synthesis of haouamine A has been achieved using cascade Mizoroki-Heck cyclization to give an indenotetrahydropyridine core. On the other hand, synthesis of a core of haouamine B using Pummerer-type cyclizations was difficult. However, this synthetic study gave us an opportunity to develop a new methodology such as iron-catalyzed radical reactions using hydrazine compounds and nitration reactions of alkenes.