Evaluation of the role of CRTH2, a novel prostaglandin D2 receptor, in higher brain function
Evaluation of the role of CRTH2, a novel prostaglandin D2 receptor, in higher brain function
批准号:
21790077
负责人:
SHINTANI Norihito
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
In this study, I aimed to determine the central function of CRTH2 by using agonists, antagonists, and knockout mice of CRTH2. I found that CRTH2 is involved in light-induced phase advance of circadian rhythm, lipopolysaccharide (LPS)-induced decrease of novel-object exploration behavior, and 15-deoxy-PGJ2 enhancement of nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. These results demonstrate for the first time the role of CRTH2 in higher brain function.
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Involvement of a prostanoid receptor CRTH2 in the LPS-induced decrease in object exploration behavior
前列腺素受体 CRTH2 参与 LPS 诱导的物体探索行为减少
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Haba R, Shintani N, et al.]
通讯作者:
et al.
Possible involvement of prostanoid CRTH2 receptor in the promoting effects of 15d-PGJ_2 on the NGF-induced neurite outgrowth in PC12 cells.
前列腺素 CRTH2 受体可能参与 15d-PGJ_2 对 NGF 诱导的 PC12 细胞神经突生长的促进作用。
DOI:
--
发表时间:
2010
期刊:
J. Pharmacol. Sci. (in press)
影响因子:
--
作者:
[Hatanaka M., et.al.]
通讯作者:
et.al.
Involvement of a prostanoid receptor CRTH2 in the LPS-induced decrease in object exploration hehavior
前列腺素受体 CRTH2 参与 LPS 诱导的物体探索行为减少
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[R.Haba, N.Shintani, et al.]
通讯作者:
et al.
精神運動機能調節におけるCRTH2受容体の役割に関する行動薬理学的検討
CRTH2受体在精神运动功能调节中的行为药理学研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[羽場亮太, 他]
通讯作者:
他
CRTH2遺伝子欠損マウスの行動薬理学的特性
CRTH2基因缺陷小鼠的行为药理学特性
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[尾中勇祐, 羽場亮太, 新谷紀人, 他]
通讯作者:
他
共 28 条
Molecular pharmacological analyses of CRTH2, the type II PGD2 receptor, as a molecule regulating emotional function
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批准号:23790086
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2011
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负责人:SHINTANI Norihito
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依托单位:
Molecular genetic study on the pathophysiology of psychiatric disorders based on the role of PACAP
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批准号:18390025
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.35万
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财政年份:2006
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负责人:SHINTANI Norihito
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依托单位:
海外基金