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Evaluation of the role of CRTH2, a novel prostaglandin D2 receptor, in higher brain function

Evaluation of the role of CRTH2, a novel prostaglandin D2 receptor, in higher brain function
评估新型前列腺素 D2 受体 CRTH2 在高级脑功能中的作用
批准号:
21790077
负责人:
SHINTANI Norihito
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
In this study, I aimed to determine the central function of CRTH2 by using agonists, antagonists, and knockout mice of CRTH2. I found that CRTH2 is involved in light-induced phase advance of circadian rhythm, lipopolysaccharide (LPS)-induced decrease of novel-object exploration behavior, and 15-deoxy-PGJ2 enhancement of nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. These results demonstrate for the first time the role of CRTH2 in higher brain function.
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Involvement of a prostanoid receptor CRTH2 in the LPS-induced decrease in object exploration behavior
前列腺素受体 CRTH2 参与 LPS 诱导的物体探索行为减少
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Haba R, Shintani N, et al.]
通讯作者: et al.
Possible involvement of prostanoid CRTH2 receptor in the promoting effects of 15d-PGJ_2 on the NGF-induced neurite outgrowth in PC12 cells.
前列腺素 CRTH2 受体可能参与 15d-PGJ_2 对 NGF 诱导的 PC12 细胞神经突生长的促进作用。
DOI: --
发表时间: 2010
期刊: J. Pharmacol. Sci. (in press)
影响因子: --
作者: [Hatanaka M., et.al.]
通讯作者: et.al.
Involvement of a prostanoid receptor CRTH2 in the LPS-induced decrease in object exploration hehavior
前列腺素受体 CRTH2 参与 LPS 诱导的物体探索行为减少
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [R.Haba, N.Shintani, et al.]
通讯作者: et al.
精神運動機能調節におけるCRTH2受容体の役割に関する行動薬理学的検討
CRTH2受体在精神运动功能调节中的行为药理学研究
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [羽場亮太, 他]
通讯作者:
28
    Molecular pharmacological analyses of CRTH2, the type II PGD2 receptor, as a molecule regulating emotional function
    • 批准号:
      23790086
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.75万
    • 财政年份:
      2011
    • 负责人:
      SHINTANI Norihito
    • 依托单位:
    Molecular genetic study on the pathophysiology of psychiatric disorders based on the role of PACAP
    • 批准号:
      18390025
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.35万
    • 财政年份:
      2006
    • 负责人:
      SHINTANI Norihito
    • 依托单位:
    海外基金