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Exploration of the drug for metabolic disorders which related to ER stress-induced rupture of adipocytes homeostasis

Exploration of the drug for metabolic disorders which related to ER stress-induced rupture of adipocytes homeostasis
内质网应激诱导的脂肪细胞稳态破裂相关代谢紊乱药物的探索
批准号:
21790153
负责人:
KAMIYA Tetsuro
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
In this study, we investigated the expression of EC-SOD in 3T3-L1 adipocytes during ER stress conditions to explore the drug for metabolic disorders. We confirmed the reduction of EC-SOD by ER stress, but not of other SOD isozymes. Moreover, we speculated that the expression of EC-SOD was regulated by eIF2α signaling cascades. Overall, we suggested that the regulation of EC-SOD during ER stress conditions might lead to improve metabolic disorders.
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単球系細胞分化過程におけるEC-SOD発現変動
单核细胞分化过程中EC-SOD表达的变化
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [神谷哲朗, 牧野純也, 原宏和, 稲垣直樹, 足立哲夫]
通讯作者: 足立哲夫
ER stress inducer, thapsigargin, decreases extracellular-superoxide dismutase through MEK/ERK signaling cascades in COS7 cells
ER 应激诱导剂毒胡萝卜素通过 COS7 细胞中的 MEK/ERK 信号级联降低细胞外超氧化物歧化酶
DOI: --
发表时间: 2011
期刊: Free Radical Research
影响因子: 3.3
作者: [田中遼大, 古川真斗, 異島優, 田中健一郎, 水島徹, 渡邊博志, 小田切優樹, 丸山徹, Tetsuro Kamiya]
通讯作者: Tetsuro Kamiya
The expression of extracellular-superoxide dismutase in 3T3-L1 adipocytes during endoplasmic reticulum stress
内质网应激时3T3-L1脂肪细胞胞外超氧化物歧化酶的表达
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Tetsuro Kamiya, Hirokazu Hara, Naoki Inagaki, Tetsuo Adachi]
通讯作者: Tetsuo Adachi
In vitro虚血誘導時のcos7細胞におけるEC-SOD発現変動
体外缺血诱导过程中cos7细胞EC-SOD表达的变化
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [小森久和, 渡邊博志, 首藤剛, 丸山徹, 小田切優樹, 神谷哲朗]
通讯作者: 神谷哲朗
13
    Exploration of the drug for atherosclerosis which related to the proliferation of smooth muscle cells-induced rupture of vascular redox homeostasis
    • 批准号:
      23790190
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.83万
    • 财政年份:
      2011
    • 负责人:
      KAMIYA Tetsuro
    • 依托单位:
    海外基金