Orthostatic tolerance and blood flow during a heat stress

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This study was focused on control of lower leg blood flow during an orthostatic challenge of heat-stressed individuals. Cutaneous vasoconstrictor responsiveness was assessed by multiple doses of exogenous norepinephrine and veno-arteriolar reflex on dorsal forearm and lower leg. Venous compliance and microvascular filtration coefficient were measured by strain-gauge plethysmography during 10mmHg pressure step test and during 20mmHg lower body negative pressure. These variables were reduced in the hyperthermic condition. In luteal phase, venous compliance and microvascular filtration were increased and orthostatic tolerance was reduced.