The role of the excitatory action of GABA in the mouse estrous cycle.

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I investigated the functional consequences of excitatory action of GABA responses on GnRH neuron physiology. A transgenic mouse was generated using tetracycline controlled gene expression system. In this mouse, KCC2 was overexpressed restricted in GnRH neurons reversibly in specific time point. This transgenic mouse could not show the pregnancy. These results suggested that the excitatory action of GABA in GnRH neurons has the important role in the regulation of the estrous cycle.