Mechanism of remodeling and functional compensation after stroke in intact hemisphere

完整半球脑卒中后重塑与功能代偿机制

• 批准号: 21790233
• 负责人: TAKATSURU Yusuke
• 金额: $ 2.66万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790233/
• 关键词: 2光子顕微鏡; 脳梗塞; In vivo imaging; In vivo microdialysis; In vivo電気生理記録; 体性感覚; 局所脳梗塞モデル; 2光子励起レーザー顕微鏡; Thy1-EYFP(H-line)マウス

Remodeling and/or synapse plasticity is increased at 1^<st> week after stroke in intact hemisphere. In contrast, recovery of general behavior is delay compared with those in simple somatosensory function. During the remodeling, glutamine, glysine and dopamine seems to be play an important role. Application of haloperidol at 2-4 days after stroke prolongs the recovery.

在脑卒中后1^< 1 bb0周，完整半球的重塑和/或突触可塑性增加。与单纯体感功能的恢复相比，一般行为的恢复是延迟的。在重塑过程中，谷氨酰胺、甘氨酸和多巴胺似乎起着重要作用。中风后2-4天应用氟哌啶醇可延长恢复时间。

项目成果

Contribution of contralateral hemisphere on functional recovery from focal infarction in somatosensory cortex

对侧半球对体感皮层局灶性梗塞功能恢复的贡献

• 发表时间: 2010
• 作者: Takatsuru Y;Fukumoto _D;Yoshitomo M;Nemoto T;Tsukada H;Koibuchi N;Nabekura J
• 通讯作者: Nabekura J

The functional remodeling of contralateral hemisphere during the recovery from the focal infarction in somatosensory cortex

体感皮层局灶性梗塞恢复过程中对侧半球的功能重塑

• 发表时间: 2009
• 作者: Y.Takatsuru;D.Fukumoto;M.Yoshitomo;T.Nemoto;H.Tsukada;J.Nabekura
• 通讯作者: J.Nabekura

Mechanism of neuronal circuit remodeling in contralateral hemisphere after cerebral infarction

脑梗死后对侧半球神经回路重塑机制

• 发表时间: 2011
• 作者: Yusuke Takatsuru;Noriyuki Koibuchi;Junichi Nabekura.
• 通讯作者: Junichi Nabekura.

Neuronal Circuit Remodeling in the Contralateral Cortical Hemisphere during Functional Recovery from Cerebral Infarction

• DOI: 10.1523/jneurosci.1638-09.2009
• 发表时间: 2009-08-12
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Takatsuru, Yusuke;Fukumoto, Dai;Nabekura, Junichi
• 通讯作者: Nabekura, Junichi

局所脳梗塞回復期の健常半球における神経回路再編機構

局灶性脑梗塞恢复过程中健康半球的神经回路重组机制

• 发表时间: 2011
• 作者: 高鶴裕介;鯉淵典之;鍋倉淳一
• 通讯作者: 鍋倉淳一