Analysis of the mechanism of photoreceptor cell death induced by retinitis pigmentosa in order to develop the new therapy.
Analysis of the mechanism of photoreceptor cell death induced by retinitis pigmentosa in order to develop the new therapy.
批准号:
21790249
负责人:
SAKAMOTO Kenji
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
Mutation in phosphodiesterase 6 genes(PDE6) causes retinitis pigmentosa(RP). The present study demonstrated that apocynin, a NADPH oxidase inhibitor, and nilvadipine, a Ca^<2+> channel blocker with an anti-oxidant effect, protect against photoreceptor cell death in the nmf363 mouse, which has a mutation in Pda6a, and the nmf137 mouse, which has a mutation in Pde6b, respectively. Therefore, these drugs may be able to use for treatment of RP patients.
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Involvement of Bradykinin in Trypsin-Induced Urinary Bladder Contraction in Cyclophosphamide-Treated Rats
缓激肽参与环磷酰胺治疗大鼠胰蛋白酶诱导的膀胱收缩
DOI:
10.1248/bpb.34.1122
发表时间:
2011
期刊:
Biological and Pharmaceutical Bulletin
影响因子:
2
作者:
[清水奈保子, 森麻美, 坂本謙司, 中原努, 石井邦雄]
通讯作者:
石井邦雄
NMDA誘発緑内障モデルにおけるcapsaicinの保護作用: CGRPの関与について
辣椒素对 NMDA 诱导的青光眼模型的保护作用:CGRP 的参与
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[坂本謙司, 黒木大陽, 森麻美, 中原努, 石井邦雄]
通讯作者:
石井邦雄
ニルバジピンはNMDAあるいはNOC12硝子体内投与誘発網膜傷害モデルラットにおける視神経細胞死を抑制する
尼伐地平抑制玻璃体内注射 NMDA 或 NOC12 诱导的视网膜损伤大鼠模型中的视神经细胞死亡
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[坂本謙司, 黒木大陽, 森麻美, 中原努, 石井邦雄]
通讯作者:
石井邦雄
L-シトルリンは網膜血管を拡張させる
L-瓜氨酸扩张视网膜血管
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[森麻美, 武井俊明, 森田匡彦, 中川智, 坂本謙司, 中原努, 石井邦雄]
通讯作者:
石井邦雄
Histoiogical protection by donepezil against neurodegeneration induced by ischemia-reperfusion in the rat retina.
多奈哌齐对大鼠视网膜缺血再灌注引起的神经变性的组织学保护。
DOI:
--
发表时间:
2010
期刊:
Journal of Pharmacological Sciences 112(3)
影响因子:
--
作者:
[坂本謙司, 大木かよ, 斉藤麻希, 中原努, 石井邦雄]
通讯作者:
石井邦雄
共 28 条
Significance of the change in the expression levels of microRNAs in neurodegenerative diseases in the retina
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批准号:15K07971
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.16万
-
财政年份:2015
-
负责人:SAKAMOTO Kenji
-
依托单位:
Role of minor iron element for developing retinal degeneration
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批准号:24590329
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2012
-
负责人:SAKAMOTO Kenji
-
依托单位:
The study of Gene-sensing systems with High speed switching by electro-fluid transistors
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批准号:23700579
-
项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
-
财政年份:2011
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负责人:SAKAMOTO Kenji
-
依托单位:
Nano-domain patterned photo-alignment layers for liquid crystal molecules
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批准号:21560023
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2009
-
负责人:SAKAMOTO Kenji
-
依托单位:
Fabrication of nano-sheets with high performance and functionality by using photo-aligned films
-
批准号:18360012
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.91万
-
财政年份:2006
-
负责人:SAKAMOTO Kenji
-
依托单位:
Investigation of photoinduced alignment mechanism of liquid crystal molecules using polyimide alignment layers
-
批准号:13450003
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.74万
-
财政年份:2001
-
负责人:SAKAMOTO Kenji
-
依托单位:
海外基金