Functional analysis of LATS2 for a conquest of tumorigenic activity of ES and iPS cells

点击翻译按钮获取中文摘要

ES and iPS cells have not only pluripotency but also tumorigenic activity, and we therefore must overcome their oncogenic property. We focused on LATS2, a tumor suppressor gene and examined the role and involvement of LATS2 in tumorigenic activity of ES cells. We found that forced LATS2 expression reduced the cell growth and oncogenic property of ES cells. However, several studies indicated that LATS2 protein expression gradually declined as ES cells grew, suggesting that there might exist the protein degradation system for the factors having anti-oncogenic activity in ES cells.