Elucidation of mechanisms of generating non-cording RNA involved in tumorigenesis and virus proliferation.

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1. We have proposed a novel tumorigenic model in which NF90-NF45 complex raised by E2F1 and 2 transactivators impairs the generation of miR-7 which is known to be an anti-oncomiR, resulting in a promotion of tumorigenesis in hepatocellular carcinoma.2. We found that an overexpression of NF90 causes muscular atrophy accompanied with mitochondrial disruption via NF90-induced translational repression of nuclear-encoded mitochondria-related proteins such as PGC-1.