Functional analysis of amplification and overexpression of c-Met in lung adenocarcinoma

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We have demonstrated that the 40 cell lines could be classified into two groups: Group I (n=22) characterized by (1) high expressions of TTF-1, MUC1,and CK7, (2) high phosphorylation of EGFR and MET, (3) frequent mutation or amplification of EGFR, MET and HER2, (4) high expressions of E-cadherin, HER3, MET, u-PA, Cox-2, and laminin γ2 and (5) sensitivity to gefitinib and resistance to cisplatin; Group II (n=18) characterized by (1) triple-negative for TTF-1, MUC1 and CK7, (2) no or a little phosphorylation of EGFR and MET, (3) no mutation or amplification of EGFR, MET and HER2, (4) high expressions of FGFR1, vimentin and TCF8 and (5) resistance to gefitinib and sensitivity to cisplatin(Matsubara et al, Am J Pathol, 2010).