Molecular mechanisms involved in human transplacental transport of anionic drug

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The transport of nonsteroidal anti-inflammatory drugs (NSAIDs) in trophoblast cells isolated from human placenta was suggested to be mediated by carrier(s), and be attributed, at least in part, to monocarboxylate transporter (MCTs). The transcellular transport of NSAIDs was examined by using isolated trophoblast cells for the first time. The present experimental system is suggested to be a potential tool to easily predict the transplacental transport of drugs in vitro.