Analysis of a potential target at SCD-1, catalytic enzyme of fatty acid, for the prevention of cardiovascular disease.

为了评估在肥胖或糖尿病患者中观察到的高血浆游离脂肪酸水平和脂肪酸催化酶对心血管疾病发病的影响，我们检查了几个基本分析。因此，我们发现饱和脂肪酸对心血管疾病有不利影响，而硬脂酰辅酶a去饱和酶-1 (SCD-1)，一种将饱和脂肪酸转化为单不饱和脂肪酸的催化酶，对饱和脂肪酸诱导的这些影响具有保护作用。总之，我们的研究结果表明，SCD-1是肥胖或糖尿病患者心血管疾病的新的预防和治疗靶点。

To evaluate the effect of high plasma levels of free fatty acid, which are observed in the patients with obesity or diabetes, and catalytic enzyme of fatty acid on the onset of cardiovascular disease, we examined several basic analyses. As a result, we identified that saturated-fatty acids adversely affect the cardiovascular disease, and stearoyl-coA desaturase-1 (SCD-1), a catalytic enzyme which converts saturated fatty acids to monounsaturated fatty acids, has a protective role against saturated-fatty acids-induced these effects. In conclusions, our results demonstrated that SCD-1 as the novel preventive and therapeutic target for cardiovascular disease in obese or diabetic patients.