Basic study for clinical application of the biomarkers for insecticide exposure

自20世纪90年代末以来，尿拟除虫菊酯(PYR)代谢物，如3-苯氧基苯甲酸(3-PBA)和有机磷(OP)代谢物，如二烷基磷酸(DAP)，已被用作环境中PYR和OP暴露最敏感的生物标志物。目的是为了阐明尿液OP和PYR代谢物的基本特征，为实际使用提供依据。我们的研究有三个主要发现。首先，最突出的发现是日本非OP接触工人和职业OP接触工人的尿DAP浓度分布，表明日本工人的尿DAP浓度与其他国家大致相同或更低。第二，尿中DAP浓度存在季节差异(夏季和冬季)。(3)OP可部分抑制PYR代谢产物3-PBA的分泌，从而减少其排泄。

Urinary pyrethroid (PYR) metabolites, e.g. 3-phenoxybenzoic acid (3-PBA), and organophosphorus insecticide (OP) metabolites, e.g. dialkylphosphate (DAP), have been used as the most sensitive biomarker for environmental PYR and OP exposure since the late 1990s. The objective is to clarify the fundamental characteristics of urinary OP and PYR metabolite for the practical usage. Our study had three major findings. First, the most salient findings are the distribution of urinary DAP concentrations in Japanese non- and occupational OP exposure workers, suggesting that the urinary DAP concentrations in Japanese workers were approximately at the same or lower levels than those in other countries. Second, there was seasonal differences of urinary DAP concentrations (summer > winter). Third, PYR metabolite, 3-PBA, excretion was decreased by co-exposure of OP due to part in carboxylesterase inhibition.